Rat Anti-Mouse CD8a mAb (AF488)

FC-5μL per test for million cells or whole blood in 100 μL volume.

Rat

AF488. Ex:490nm.Em:525nm.

Unmodified

12525

Mouse CD8a

IgG2a

Monoclonal Antibody

53-6.7

A synthesized peptide derived from Mouse CD8a

Immunology

CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

Affinity Purified

Liquid

Liquid in PBS with 0.05% Proclin300, 1% BSA

Store at 2-8°C..Avoid light.Avoid freeze/thaw cycles.